由Corynebacterium diphtheriae引起的呼吸道白喉症的本土爆发,德国,2024年9月
Anja Berger1,2,3,4, Alexandra Dangel5,3, Katja Bengs3
1World Health Organization (WHO) Collaborating Centre for Diphtheria, Oberschleißheim, Germany.
概括
自1984年以来,德国首次发生严重的呼吸道白喉疫情,导致一名儿童死亡.
科学领域:
- 公共卫生和流行病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 严重的细菌感染 - - 脊髓灰质炎在某些人群中出现了复苏.
- 有毒的Corynebacterium diphtheriae菌株对公众健康构成重大威胁.
- 最近的疫情与脆弱群体有关,包括移民和无家可归人口.
研究的目的:
- 调查自1984年以来德国首次发生的本土呼吸道白喉疫情.
- 确定致病原体的分子流行病学和传播动态.
- 评估皮肤和呼吸道白喉病例之间的联系.
主要方法:
- 在未接种疫苗的儿童中对致命的呼吸道白喉病例的流行病学调查.
- 使用多位置序列类型 (MLST) 和核心基因组 (cg) 进行细菌分离体的表征.MLST.
- 隔离物与皮质耳病例和国际爆发病例的隔离物进行比较.
主要成果:
- 一个严重的呼吸道白喉病例和一个未接种疫苗的孩子的死亡,与母亲的感染有关.
- 分子类型确定了母婴对的克隆分离物 (ST 574),表明最近的传播.
- 隔离品与皮肤白喉病例和国际爆发病例的菌株具有遗传相似性,这表明传播范围更广.
结论:
- 这项研究证实了自1984年以来德国首次出现呼吸道白喉疫情,强调了这种疾病的重新出现.
- 研究结果表明,Corynebacterium diphtheriae可以扩散到弱势群体之外,并导致严重的呼吸道疾病.
- 保持高疫苗接种率至关重要,以防止严重的耳病例和疫情爆发.
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