内分泌干扰效应的模型:人类胎盘类固醇生成
Line Mathiesen1, Dea Sandal1, Ida Elise Moelgaard Hammer1
1Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark.
Basic & clinical pharmacology & toxicology
|July 11, 2025
概括
怀孕期间内分泌干扰的研究越来越多. 这项研究审查了人类胎盘模型来评估内分泌干扰化合物,强调需要对胎盘类固醇生成进行更多研究.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 怀孕期间内分泌干扰与不利的胎儿生长和晚年健康问题有关.
- 人类胎盘独特的类固醇生成途径为建模内分泌干扰带来了挑战.
- 对于精确评估内分泌干扰化合物的风险,人类模型是首选的.
研究的目的:
- 审查现有的人类胎盘模型来研究内分泌干扰.
- 评估各种模型对评估胎盘类固醇生成的适用性.
- 确定研究缺口,并建议该领域的未来方向.
主要方法:
- 对人类胎盘模型现有文献的审查.
- 模型的分类包括胎盘 perfusion,扩充剂,细胞培养和胎盘在芯片上的系统.
- 基于其复制人类胎盘类固醇生成的能力的模型分析.
主要成果:
- 存在几种人类胎盘模型,包括胎盘输液,扩充剂和各种细胞培养 (BeWo,HTR-8/SVneo,Jar,JEG-3,ACH-3P).
- 这些模型为研究胎盘类固醇生成和激素产生提供了不同的优势和局限性.
- 发现显著缺乏专门针对胎盘类固醇生成和内分泌干扰化合物的研究.
结论:
- 现有的人类胎盘模型在完全复制胎盘类固醇生成方面存在局限性.
- 需要进一步的研究来开发和验证评估内分泌干扰化合物对胎盘影响的模型.
- 改进的模型对于准确的人类风险评估和理解与怀孕相关的内分泌干扰至关重要.
更多相关视频
09:15Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
23.0K
08:28Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
Published on: April 26, 2018
6.1K
相关概念视频
01:07Teratogenicity
2.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.8K
01:24Gonadal and Placental Hormones
1.8K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.8K