关于天然脂的脱酸基希夫衍生物作为潜在的抗真菌剂的研究
Renle Xu1, Jinhang Ma1, Runhe Huang1
1Key Laboratory of Biomass Energy and Material, College of Forestry, Northwest A&F University, Yangling, Shaanxi Province 712100, P. R. China.
Journal of agricultural and food chemistry
|July 11, 2025
概括
一种新的脂基杀菌剂通过破坏真菌结构和抑制关键酶,有效控制菌冠. 这种环保的化合物显示出保护小麦作物的前景.
科学领域:
- 农业化学 农业化学
- 菌类学 菌类学是指菌类学.
- 有机合成 有机合成
背景情况:
- 虫冠状腐烂对全球小麦产量构成重大威胁.
- 开发环保和有效的杀菌剂对于可持续农业至关重要.
- 脂基化合物为新型抗真菌剂提供了潜在的途径.
研究的目的:
- 设计和合成基于Schiff的新型脱乙烯衍生物作为潜在的杀菌剂.
- 评估这些化合物的体外和体内疗效,以对抗*Fusarium pseudograminearum*.
- 阐明最有效衍生品的作用机制.
主要方法:
- 基于Schiff的脱乙烯衍生物的合成.
- 使用FT-IR,NMR (H,C) 和LC-MS进行了表征.
- 在体外抗真菌活性测定对*Fusarium pseudograminearum*.
- 在小麦植物的体内保护作用评估.
- 细胞形态和超结构分析.
- 活性氧物种 (ROS) 的染色.
- 酶活性测定 (SOD,POD,CAT,PPO) 进行.
- 分子对接研究. 分子对接研究.
主要成果:
- 化合物4o (Co. 4o) 在体外显著抑制了*Fusarium pseudograminearum*的生长 (EC50=5.45μg/mL).
- 在小麦植物中,Co. 4o表现出对 fusarium 冠状腐烂的保护作用.
- 显微镜分析显示,在Co. 4o治疗后,真菌菌和超结构受到严重损害.
- 观察到ROS的积累和主要真菌酶 (SOD,POD,CAT,PPO) 的抑制.
- 分子对接表明了Schiff基组和氨基酸之间的键相互作用.
结论:
- 基于Schiff的脱水乙衍生品Co. 4o是一种强大且环保的杀菌剂候选物.
- Co. 4o通过破坏真菌细胞形态,诱导ROS和抑制必需酶来起作用.
- 这种化合物显示出对控制小麦中fusarium皇冠腐烂的显著潜力.
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