测量不确定性和前列腺健康指数-一篇评论
Ian Farrance1, Robert Frenkel2
1Discipline of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.
The journal of applied laboratory medicine
|July 11, 2025
概括
计算值的测量不确定性 (MU),如前列腺健康指数 (PHI),对于临床解释至关重要. 测量不确定性表达指南 (GUM) 提供了比内部质量控制 (IQC) 方法更准确的MU估计,特别是当包括相关性术语时.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 测量科学 测量科学
背景情况:
- 许多医学实验室值是计算的,而不是直接测量.
- 计算量的测量不确定性 (MU) 对于临床解释至关重要,但经常被忽视.
- 前列腺健康指数 (PHI) 有助于评估前列腺癌.
研究的目的:
- 评估前列腺健康指数 (PHI) 的测量不确定性 (MU) 使用测量不确定性表达指南 (GUM) 程序.
- 将GUM方法与使用内部质量控制 (IQC) 进行MU估计的新方法进行比较.
- 为了证明相关性术语对PHI的MU计算的影响.
主要方法:
- 应用GUM程序对PHI进行全面的MU评估.
- 使用GUM和直接IQC方法计算PHI的MU.
- 在GUM框架中包含的相关性条款.
主要成果:
- 与相关性相关的GUM方法产生了3.60%的相对标准不确定性,平均PHI为24.48.
- 直接IQC程序导致7.2%的较高相对标准不确定性.
- 使用GUM的无相关性MU为5.99%,突出显示了相关性术语的影响.
结论:
- 在计算 PHI 的 MU 时,GUM 方法是优越的,特别是在包含相关性时.
- 用于MU估计的直接IQC方法可能会高估不确定性,并且不考虑相关性.
- 准确的MU评估对于可靠的临床解释计算的诊断值至关重要.
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