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Updated: Sep 16, 2025

Inducible and Reversible Dominant-negative DN Protein Inhibition
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通过PAX5::CBFA2T3对PAX5转录活性进行双向抑制

Reina Ueno1, Aki Terasaki1, Yuiko Imai1

  • 1Division of Cellular and Genetic Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Japan.

FEBS open bio
|July 11, 2025
PubMed
概括

B细胞急性淋巴细胞白血病中PAX5::CBFA2T3融合蛋白通过两个不同的机制抑制PAX5基因活性:DNA结合和HDAC招募. 这为B-ALL病原体提供了新的见解.

关键词:
在PAX5中使用PAX5.急性淋巴细胞白血病急性淋巴细胞白血病融合基因 融合基因 融合基因希斯顿脱乙酶的使用

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