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Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
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Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

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The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
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Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

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Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
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相关实验视频

Updated: Sep 16, 2025

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
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Germ Cell Transplantation and Testis Tissue Xenografting in Mice

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存储和贩运黄激素的储存和贩运

Asia Ingram1, T Rajendra Kumar1,2

  • 1Integrated Physiology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Andrology
|July 11, 2025
PubMed
概括
此摘要是机器生成的。

通过白化激素 (LH) 途径改变毛囊刺激激素 (FSH) 分泌,可以增强女性的排卵. 在雄性小鼠中,转向FSH没有显示任何功能性改善,突出了性别特定的生殖机制.

关键词:
在FSH中,FSH是FSH.LH LH LH LH LH LH LH LH LH LH LH LH LH LH密集的核心颗粒.这是一种性腺激素 (gonadotropin).pituitary pituitary pituitary pituitary pituitary pituitary pituitary pituitary pituitary pituitary 下垂体 下垂体 下垂体 下垂体 下垂体 下垂体 下垂体这是一种分泌的分泌.

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An Ex vivo Model to Study Hormone Action in the Human Breast
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An Ex vivo Model to Study Hormone Action in the Human Breast

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Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

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相关实验视频

Last Updated: Sep 16, 2025

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
10:41

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Published on: February 6, 2012

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An Ex vivo Model to Study Hormone Action in the Human Breast
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An Ex vivo Model to Study Hormone Action in the Human Breast

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科学领域:

  • 生殖生物学 生殖生物学
  • 内分泌学 在内分泌学.
  • 分子内分泌学分子内分泌学

背景情况:

  • 淋巴激素,白质化激素 (LH) 和卵泡刺激激素 (FSH),对于脊椎动物的繁殖至关重要.
  • 在淋巴细胞中合成的LH和FSH表现出不同的储存和分泌模式.
  • FSH主要通过构成性分泌,而LH通过受调节的途径储存和释放.

研究的目的:

  • 为了比较审查脊椎动物物种中的淋巴激素储存和分泌模式.
  • 阐明控制差异性性腺激素贩运和释放的分子机制.

主要方法:

  • 在从原始鱼类到哺乳动物的脊椎动物中对性腺激素储存的比较分析.
  • 批判性讨论体外和体内研究关于性腺激素的贩运和分泌的研究.

主要成果:

  • 从原始鱼类中单一的淋巴激素的演变,到脊椎动物中明显的LH和FSH.
  • 在远鱼中存在单激素性淋巴体,在高脊椎动物中存在双激素性淋巴体.
  • 识别LHβ碳酸终端七作为调节分泌途径分类的关键决定因素.

结论:

  • 在转基因小鼠中,工程FSH利用受调节的分泌途径 (通过LHβ七融合) 提高了雌性卵射和卵巢存活率.
  • 没有观察到重定向FSH的雄性小鼠的功能增长,这表明性别特异性影响.
  • 了解这些机制为提高女性生殖功能和寿命提供了临床应用的潜力.