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在膀癌中个性化药物的证据差距地图

Hadi Mostafaei^1,2, Hanieh Salehi-Pourmehr², Fatemeh Sadeghi Ghyassi²

¹Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Personalized medicine

|July 11, 2025

概括

这项研究绘制了膀癌个性化医学的证据,发现大多数研究重点是免疫疗法和基因疗法,但往往缺乏高质量的数据. 改善研究设计对于临床创新至关重要.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
证据综合证据综合

背景情况:

个性化医学 (PM) 为膀癌提供了量身定制的治疗策略.
高层次的证据综合对于理解目前在膀癌中PM的研究环境至关重要.

研究的目的:

在膀癌中创建个性化医学研究的证据差距地图 (EGM).
确定膀癌PM的研究缺口和研究不足的领域.
评估在膀癌中PM现有证据的质量.

主要方法:

在2024年6月之前进行全面的文献搜索.
使用PubMed数据进行科学度分析.
与R Studio和Biblioshiny同时进行单词网络分析.

主要成果:

选择了3,705篇文章,其中关键词包括瘤,预后和基因表达.
免疫疗法,新辅助/辅助疗法和基因疗法是研究最多的领域.
证据质量主要是低到中等,特别是在免疫疗法和生物标志物的临床试验中.

结论:

膀癌中PM的领域需要更强大的研究方法和合作.
提高研究设计和数据质量对于将发现转化为临床实践至关重要.
分子分析和向治疗是改善膀癌治疗策略和患者治疗结果的关键.

关键词:

生物标志物生物标志物个性化医疗是个性化的医疗.膀癌:膀癌是一种癌症.临床证据临床证据证据差距地图证据差距地图精确瘤学精确瘤学有针对性的治疗.

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