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Updated: Sep 8, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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IMPDH的理性稳定抑制状态提出了一种新的准方法,涉及其跨域和装配抑制

Samira Sattari1, Razieh Yazdanparast2, Ebrahim Barzegari3,4

  • 1Institute of Biochemistry and Biophysics, University of Tehran, Tehran, 1417614335, Iran.

Molecular biotechnology
|July 11, 2025
PubMed
概括

针对因诺辛单酸脱酶 (IMPDH) 上的ATP位点1的突变可以抑制GTP生物合成,通过稳定酶的非活性形式,为视网膜炎色素治疗提供了一种新的策略.

关键词:
双重抑制可以抑制.发光线组件的发光线组合.伊诺单酸盐脱酶酶的使用分子动力学分子动力学有理性的突变发生.视网膜炎的颜色素

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