对结直肠癌的新型向机制的最新进展
Zhiping Li1, Hailing Wang1, Yan Liu1
1School of Pharmacy, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Harbin, 150040, People's Republic of China.
概括
结直肠癌 (CRC) 新型向策略侧重于代谢重编程,细胞死亡和信号通路,以克服药物耐药性和转移. 本综述综合了改善CRC治疗疗效的新兴机制.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 大肠直肠癌 (CRC) 是癌症死亡的主要原因,治疗挑战包括耐药性,转移和瘤异质性.
- 了解瘤生物学揭示了对CRC进展和治疗至关重要的新的向机制.
- 代谢重编程,细胞死亡和信号通路是CRC的关键生物过程,提供可操作的治疗点.
研究的目的:
- 系统地审查和综合最近在结直肠癌的新目标机制的进展.
- 突出新兴的策略,重点关注代谢重编程,细胞死亡和信号通路.
- 为克服CRC挑战,如转移和化疗抵抗提供治疗见解.
主要方法:
- 关于结直肠癌向机制近期进展的文献综述.
- 合成有关代谢变化,非编码RNA,肠道微生物群,细胞外囊泡和机械应激信号的信息.
- 集成关于信号通路的数据,如AKT/mTOR,TP53,TYMS,FAK-Rho-ROCK,和Wnt-YAP1.3等数据.
主要成果:
- 代谢途径 (甲素,叶酸,血清素,聚胺) 涉及到CRC的发病过程.
- 非编码RNAs (lncRNAs CKMT2-AS1,H19;miRNA-375-3p) 调节影响增殖,亡和化学抵抗的关键信号通路.
- 肠道微生物群调节和细胞外囊泡在免疫逃避,转移和治疗敏感化中发挥作用.
- 机械应力信号通路调节CRC细胞迁移,入侵和干细胞.
结论:
- 针对代谢重编程,细胞死亡和信号通路提供了有希望的策略,以提高CRC治疗疗效.
- 涉及肠道微生物群和细胞外囊泡的新方法提供了新的治疗途径.
- 本综述通过整合多方面的向机制来解决文献中的差距,以对抗CRC转移和化学抵抗.
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