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年轻成年人的长期肥胖和生物衰老
Paulina Correa-Burrows1,2, Raquel Burrows1, Cecilia Albala1,2
1Institute of Nutrition & Food Technology, Universidad de Chile, Santiago, Chile.
JAMA network open
|July 11, 2025
概括
年轻人的长期肥胖与加速的生物衰老标志物有关,这表明早期慢性疾病的可能性. 这项研究强调了肥胖持续时间对衰老指标的影响.
科学领域:
- 生物医学科学 生物医学科学
- 衰老研究研究 衰老研究
- 肥胖研究 肥胖研究
背景情况:
- 肥胖对加速生物衰老和早期慢性疾病发病的影响尚不清楚.
- 了解年轻人长期肥胖和衰老标志物之间的联系对于公共卫生至关重要.
研究的目的:
- 调查28-31岁成年人长期肥胖和生物化学衰老标志物之间的关联.
- 探索肥胖持续时间如何影响表观遗传改变,炎症和细胞衰老的标志物.
主要方法:
- 一个用前智利出生队列 (圣地亚哥纵向研究) 的数据进行的病例控制研究.
- 分析自出生以来的体重指数 (BMI) 轨迹,将参与者分为健康的BMI,持续的青少年或持续的儿童肥胖群体.
- 评估基于DNA甲基化的年龄,端粒长度 (TL) 和与衰老相关的细胞因子,生长因子和脂肪因子.
主要成果:
- 长期的肥胖,特别是从童年开始,与增加的炎症标志物水平显著相关,如hs-CRP和IL-6.
- 肥胖的持续时间与衰老特征的表达变化相关,包括FGF-21,IGF-1,IGF-2,阿佩林和虹膜素.
- 长期肥胖与这些生物化学衰老标志物之间的关联观察到一个很大的效果大小.
结论:
- 年轻人的长期肥胖与生化衰老标志物有关,这些标志物表明生物衰老加速.
- 研究结果表明,年轻人的慢性健康问题可能源于肥胖引起的生物衰老.
- 这项研究强调了早期肥胖干预的重要性,以减轻长期健康后果.
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