肌缩侧面硬化症的流行病学:基于人口的分析,2015-2020年
Bernat Bertran-Recasens1,2, Sergio Vidal-Notari1,2, Guillem Hernández Guillamet3,4
1ALS/Motor Neuron Diseases Unit, Neurology Department, Hospital del Mar, Barcelona, Spain.
概括
这项研究显示,加泰罗尼亚的肌缩性侧面硬化症 (ALS) 比以前认为的更高,痴呆症和酒影响了生存率. 结果提供了对ALS进展和预后的见解.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在西班牙,关于肌缩侧面硬化症 (ALS) 的流行病学数据有限.
- 之前的研究集中在小群体中,生存率和并发症信息不足.
- 这项研究为西班牙加泰罗尼亚的一个大型,特征明确的ALS队列提供了10年的随访.
研究的目的:
- 确定加泰罗尼亚地区ALS的发病率,流行率和领土分布.
- 在大型ALS队列中分析并发症,死亡率和生存时间.
- 确定死亡率的预测因素,并了解影响ALS进展的因素.
主要方法:
- 一项使用初级保健研究发展信息系统 (SIDIAP) 数据库的观察性研究.
- 从2015年到2020年,包括6,301,095个人的健康记录.
- 使用多变量分析评估ALS病例,并发症,存活率和死亡率.
主要成果:
- 2015-2020年间确诊的ALS病例为1173例;诊断时的中位数年龄为68岁;女性占50.4%.
- 病发率:每10万人/年2.39/10万人;流行率:每10万人/年7.98/10万人.
- 痴呆症 (6.8%) 和抑郁症/焦虑症 (45.7%) 是常见的并发症. 平均存活时间:2.19年. 老年,滥用酒精,中风和痴呆症预测死亡率.
结论:
- 加泰罗尼亚的ALS发病率和流行率超过了之前的西班牙估计,与西欧的比例保持一致.
- 诊断时的年龄较大,滥用酒精,中风史和痴呆症是减少生存时间的重要预测因素.
- 这些发现突出了肌缩性侧面硬化症的关键预后因素,有助于了解疾病的进展.
相关概念视频
Parkinson's Disease: Overview
715
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
715
Amyloid Fibrils
9.9K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.9K
Prevalence and Incidence
825
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
825
Cross-bridge Cycle
118.3K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
118.3K
Alzheimer's Disease: Overview
673
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
673


