鼻癌患者的萨尔科佩尼亚的预后值:一个元分析
1Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Annals of medicine
|July 11, 2025
概括
鼻癌是鼻癌 (NPC) 患者不良结果的重要预测因素,对整体存活率和无进展存活率产生负面影响. 这种情况也与NPC的高级T阶段有关.
科学领域:
- 在瘤学瘤学.
- 临床医学 临床医学
- 预测 预测 预测 预测 预测
背景情况:
- 萨科佩尼亚在鼻癌 (NPC) 预后中的作用是有争议的,因为研究结果不一致.
- 这一元分析旨在澄清NPC中sarcopenia的精确预后价值.
研究的目的:
- 系统地评估萨科佩尼亚作为鼻癌 (NPC) 的预后标志物.
- 评估NPC患者的肉类和生存结果 (总生存率和无进展生存率) 之间的关联.
- 为了调查sarcopenia和NPC的临床病理特征之间的关系.
主要方法:
- 在PubMed,科学网,Embase和Cochrane图书馆进行了系统的文献搜索.
- 进行了元分析,以确定 95% 置信区间 (CI) 的聚合危险比率 (HRs) 和赔率比率 (ORs).
- 包括8项涉及5458个NPC病例的研究.
主要成果:
- 在NPC中,肉症与不利的整体存活率 (HR = 1.88) 和无进展存活率 (HR = 2.03) 有意义地相关.
- 发现了萨尔科佩尼亚和较高的T阶段 (OR = 1.33) 之间存在显著的关联.
- 在sarcopenia和性别,N阶段或TNM阶段之间没有发现显著的关联.
结论:
- 麻症是NPC患者总生存率降低和无进展生存率的重要预后指标.
- 在NPC中较高的T阶段与肉类的存在有显著的关联.
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