黑色素瘤细胞通过一种依赖于黑色素的机制抑制巨细胞功能
Fábio Rabelo Melo1, Lea Nyman1, Ida Österman Menander1
1Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden.
The FEBS journal
|July 11, 2025
概括
黑色素瘤细胞通过黑色素抑制杆细胞 (MC) 的生长和功能. 这种黑色素被MCs吸收,特别是在核中,损害了MC激活和生存,可能影响瘤免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 癌症生物学 癌症生物学
背景情况:
- 乳腺母细胞 (MCs) 以它们在过敏中的作用和它们对包括黑色素瘤在内的各种癌症的影响而闻名.
- 以前的研究集中在MCs如何影响黑色素瘤,但黑色素瘤对MCs的影响仍未得到充分探索.
研究的目的:
- 为了研究黑色素瘤细胞对乳腺癌细胞的影响.
- 为了阐明黑色素瘤诱导的巨细胞抑制的潜在机制.
主要方法:
- 用黑色素瘤细胞调节介质和分离的黑色素治疗培养的巨细胞.
- 分析巨细胞增殖,细胞亡,标记物表达和激活.
- 调查黑色素的吸收,核定位,以及对瘤细胞核形态和组织蛋白修饰的影响.
- 评估三酶转位及其在黑色素诱导的细胞死亡中的作用.
主要成果:
- 黑色素瘤细胞受条件的介质显著抑制了巨细胞的增殖和诱导的亡.
- 从黑色素瘤细胞中分离或直接添加的黑色素是这些抑制作用的原因.
- 黑色素损害了巨细胞的激活,而没有改变关键的表面标记物.
- 黑色素被巨细胞内化,定位在核内,并诱导核形态的变化.
- 酸转移到核中介于黑色素诱导的核变化,并影响细胞死亡途径.
结论:
- 黑色素瘤细胞通过黑色素抑制巨细胞的功能和活力,代表了一种新的免疫抑制机制.
- 黑色素的核转位和与三酶的相互作用是抑制巨细胞活动的关键.
- 这种由黑色素瘤诱导的巨细胞抑制可能会导致免疫逃避和瘤进展.
相关概念视频
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
01:19Pigmentation
2.7K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.7K
01:30Skin Cancer
4.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.6K
02:38Mitogens and the Cell Cycle
6.9K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.9K
01:15Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K
02:17The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K