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Updated: Sep 16, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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UFMylation通过激活duebiquitinase BAP1来维持瘤抑制剂pVHL的稳定性

Xiao Yang1, Yalei Wen2, Shengying Qin3,4

  • 1State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China/College of Pharmacy, Jinan University, Guangzhou 510632, China.

Science advances
|July 11, 2025
PubMed
概括

BRCA1相关蛋白1 (BAP1) 通过稳定pVHL蛋白来抑制结直肠癌 (CRC). BAP1的UFMylation对于这种瘤抑制功能至关重要,其损失与CRC预后不佳有关.

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