骨髓中性粒细胞密度调节肥胖和减肥期间的骨髓形成
Quin T Waterbury1,2, Jin Qian1, Hualong Zheng1,3
1Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
The Journal of experimental medicine
|July 11, 2025
概括
肥胖会改变骨髓 (BM) 以增加骨髓细胞的产生. 来自BM的中性粒细胞招募推动了这一点,即使在减肥后也持续存在,这表明肥胖相关炎症的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 代谢性疾病研究研究.
背景情况:
- 肥胖会改变骨髓 (BM) 功能,促进骨髓细胞的产生.
- 导致肥胖的BM变化的精确机制尚未完全理解.
研究的目的:
- 阐明 obesity,骨髓变化和炎症之间的机制.
- 调查中性粒细胞招募在肥胖引起的骨髓形成中的作用及其在减肥后的持久性.
主要方法:
- 利用肥胖和减肥的小鼠模型.
- 研究了从BM到脂肪组织中的中性粒细胞的招募.
- 评估了造血干细胞激活和髓状细胞的产生.
- 在肥胖的人群中测量了血中性粒细胞化学因子和胰岛素抵抗.
主要成果:
- 肥胖刺激诱导脂肪组织巨细胞从BM中招募中性粒细胞.
- 中性粒细胞的招募激活了造血干细胞,导致循环髓状细胞的积累和炎症.
- 这种由中性粒细胞驱动的骨髓形成在减肥后持续存在.
- 抑制中性粒细胞的招募减少了BM骨髓形成,脂肪组织炎症,并改善了葡萄糖耐受性.
- 肥胖的人群表现出血中性粒细胞化学因子的增加,这与胰岛素抵抗有关,并且不会随着体重减轻而减少.
结论:
- 从骨髓中招募中性粒细胞是肥胖症中骨髓形成的关键媒介.
- 这一途径有助于持续的炎症和代谢功能障碍.
- 针对中性粒细胞的招募是一个潜在的治疗策略,用于管理肥胖和体重减轻后的炎症.
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