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Updated: Sep 16, 2025

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在北印度的晚期细胞癌中生殖系变异的流行率

Chitrakshi Nagpal1, Mohit Kumar Divakar1, Hemavathi Baskarane1

  • 1Department of Medical Oncology, Dr B.R.A. IRCH, AIIMS, New Delhi, India.

JCO global oncology
|July 11, 2025
PubMed
概括

在晚期细胞癌 (RCC) 患者中,即使没有高风险特征,生殖细胞突变也很常见. 对所有晚期RCC病例来说,基因检测对于家族查和未来治疗选择至关重要.

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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