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在临床阶段试验中T细胞诱导毒性;系统性审查和元分析

Zoulikha M Zaïr¹, Gemma Butterworth¹, Mariam Shalaby²

¹The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.

Cancer treatment reviews

|July 11, 2025

概括

T细胞参与剂 (TCE) 对固体瘤有前途,但有毒性问题. 这次审查发现胃肠道和炎症毒性是最常见的,Fc独立的TCE可能会减少炎症.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
临床试验临床试验

背景情况:

T细胞参与者 (TCE) 激活患者的免疫系统以向瘤抗原.
在固体瘤中,TCE疗法面临挑战,主要是由于不良的毒性概况.
了解TCE毒性对于在固体瘤中更广泛的临床应用至关重要.

研究的目的:

系统地审查和元分析用于治疗固体瘤的T细胞参与剂 (TCE) 的毒性概况.
确定在固体瘤治疗中与TCE相关的最普遍的毒性.
探索影响TCE相关毒性的因素,包括连接体类型和信号通路.

主要方法:

在主要数据库 (MEDLINE,科克兰图书馆等) 进行系统的文献搜索. ) 的情况.
包括30个系统审查和21个元分析的出版物.
使用逆方差方法和限制最大概率估计器汇集的流行数据.

主要成果:

胃肠道和炎症毒性是最常见的不良事件.
胃肠道毒性独立于瘤类型或结合体.
独立于Fc的TCE显示出较低炎症毒性的趋势,尽管细胞因子释放综合征 (CRS) 可能未得到报告.

结论:

TCE的毒性概况各不相同,胃肠道和炎症影响是关键问题.
需要对Fc独立的TCE进行进一步的研究,并改进CRS的报告.
识别改善TCE耐受性的特征对于推进它们在固体瘤中的应用至关重要.

关键词:

临床试验中的临床试验.固体瘤是一种固体瘤.这些T细胞参与者.有毒性有毒性

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