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氧化纳米粒子在体内分布和转化行为中介肠道运输功能

Chunli Lei¹, Rui Liang¹, Bingxu Cheng¹

¹Institute of Environmental Processes and Pollution Control, and School of Environment and Ecology, Jiangnan University, Wuxi, Jiangsu 214122, China.

Ecotoxicology and environmental safety

|July 11, 2025

概括

在小鼠中持续摄入氧化纳米颗粒 (CeO2 NPs) 表明它们在便中分泌,但在消化组织中积累. 这些NP通过Ce3+/Ce4+电子转移缓解反应性氧物种 (ROS),保持肠道功能.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
纳米技术纳米技术

背景情况:

暴露于氧化纳米粒子 (CeO2NP) 可能是通过食物链.
不断摄入CeO2NP对肠道微生态系统的影响尚不清楚.
调查CeO2 NP分布和体内生理影响至关重要.

研究的目的:

调查持续摄入后CeO2NP在体内分布的情况.
阐明生物化学机制,特别是Ce3+/Ce4+电子转换,参与ROS消除.
评估CeO2NP对肠道生理功能和微生物共同参与的影响.

主要方法:

在28天的时间里,小鼠接受了CeO2NP (10 mg/kg·bw/day) 治疗.
进行了组织分布分析,以量化NP积累.
生物化学分析测量了反应性氧物种 (ROS) 水平和氧化还原过程.

主要成果:

CeO2 NPs主要通过便排泄 (51.49%),其余水平在所有组织中发现,特别是胃 (36.78%) 和肠道 (4.44%).
CeO2 NPs在肠道中积累,参与氧化还原过程并缓解运输功能中断.
Ce3+/Ce4+电子转移显著减少了329.2%的过氧化 (H2O2),并减轻了微生物ROS的产生.

结论:

摄入CeO2 NP会导致在消化组织中的分泌和积累.
Ce3+/Ce4+电子转移机制是减少肠道ROS和保持运输能力的关键.
这项研究提供了CeO2 NP生理命运和氧化还原效应的见解,为人类健康风险评估提供了信息.

关键词:

CeO (((2) NPs 已经成为一个国家.电子过渡的电子过渡过程肠道的微生物群.这就是ROSOS ROS.运输能力运输能力

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