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使用表面和X射线成像进行实时体积CBCT重建,用于图像引导放射治疗

Shaoyan Pan¹, Vanessa Su², Junbo Peng³

¹Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA; Department of Computer Science, Emory University, Atlanta, GA 30322, USA; Department of Biomedical Informatics, Emory University, Atlanta, GA 30322, USA.

Medical image analysis

|July 11, 2025

概括

这项研究引入了一种用于放射治疗期间实时瘤运动跟踪的新框架. 它将光学表面成像与低剂量X射线投影相结合,生成精确的形光束CT图像,提高治疗精度.

科学领域:

医疗成像医学成像
辐射瘤学辐射瘤学
计算成像技术的成像

背景情况:

光学表面成像 (OSI) 追踪患者的外部运动,但缺乏内部瘤可见性.
圆束CT (CBCT) 提供了内部解剖学,但通常在较高的辐射剂量和较低的时间分辨率.
精确的瘤运动跟踪对于有效的图像引导放射治疗 (IGRT) 是至关重要的.

研究的目的:

开发一个实时体积成像框架,用于IGRT中精确的瘤运动跟踪.
将表面成像与有限的X射线数据集成为低剂量,高保真性CBCT重建.
为了提高放射治疗期间内部瘤定位的准确性.

主要方法:

开发了一种物理整合一致性精细化无效扩散概率模型 (PC-DDPM).
该框架将高频OSI数据与低频单角X射线投影集成在一起.
一个几何转换模块 (GTM) 从X射线数据中提取了解剖信息,以指导生成模型.

主要成果:

拟议的框架成功地产生了高保真度光表面衍生CBCT (OSD-CBCT) 的数量.
通过多种评估指标实现了精确的瘤定位,并得到了验证.
PC-DDPM利用来自4DCT的患者特定解剖学和运动模式进行重建.

结论:

开发的框架可实现实时,低剂量体积成像,用于精确的瘤跟踪.
这种方法推进了对运动敏感辐射疗法的图像引导技术.
这些发现显示了在需要实时成像的干预程序中提高准确性的潜力.

关键词:

在CBCT重建的重建.扩散模型是一个扩散模型.表面成像表面成像在X射线成像中使用X射线成像.

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