表观遗传年龄与沿皮层组织的感觉运动与关联轴的区域大脑衰老有关
Nicholas Riccardi1, Carolyn Banister2, Natalie Busby1
1Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, United States.
Neurobiology of aging
|July 11, 2025
概括
表观遗传年龄 (DNAmAge) 影响大脑衰老,特别是在高阶大脑区域. 这种生物钟可能反映了细胞衰老过程,影响整个成年期的大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 大脑年龄和表观遗传年龄 (DNAmAge) 是与健康相关的独立生物钟.
- 大脑衰老和DNAmAge之间的确切关系尚未完全理解.
研究的目的:
- 通过路径分析,研究时间年龄,DNAmAge和大脑年龄之间的关系.
- 探索特定大脑区域的晚年衰老是否与DNAmAge相关.
主要方法:
- 149名参与者 (20-80岁) 的MRI估计的大脑年龄 (全球和区域).
- 从全血中计算出四个DNAmAges:Phen,Hannum,Horvath和SkinBlood. 这四个DNAmAge是从全血中计算出来的.
- 调解分析用于测试DNAmAge和全球BrainAge之间的间接影响,以时间年龄为独立变量.
主要成果:
- DNAmPhenoAge调解了时间年龄和全球BrainAge之间的关系.
- DNAmPhenoAge与沿传感运动到关联轴的大脑区域的高级BrainAge相关.
- 高阶关联皮层的生物衰老与表观遗传衰老有关.
结论:
- DNAmPhenoAge可以独特地捕捉到与大脑健康相关的细胞衰老过程.
- 特定区域的发现突出显示了表观遗传衰老和高阶大脑区域的生物衰老之间的联系.
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