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解开功能性消化不良:病理生理机制,微生物群相互作用和新兴的治疗策略
Aisi Huang1, Bixia Lin1, Tao Hu1
1Shenzhen Baoan District Hospital of Chinese Medicine, Shenzhen 518000, China.
Pathology, research and practice
|July 11, 2025
概括
本综述探讨功能性消化不良 (FD) 的机制,重点关注肠道微生物群的作用. 它合成了西方和传统中医疗的治疗方法,以提供个性化的患者护理.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 综合医学是一个整体的医学.
背景情况:
- 功能性消化不良 (FD) 是一种普遍存在的胃肠道疾病,具有复杂和多因素的病理生理学.
- 目前的理解突出了胃肠道运动障碍,内脏过敏和改变肠道微生物群的作用.
- 现有的治疗策略具有可变的疗效,需要新的方法.
研究的目的:
- 为了解功能性消化不良 (FD) 的最新进展提供全面的概述.
- 阐明FD复杂的病理生理机制,重点关注肠道微生物群.
- 综合当前和新兴的治疗策略,整合西方和传统中医 (TCM) 的范式.
主要方法:
- 系统性文献审查FD中的病理生理机制.
- 分析肠道微生物群在FD病变发生中的作用及其与宿主相互作用.
- 综合各种治疗干预措施,包括饮食,药物,行为和TCM方法.
主要成果:
- FD的发病包括胃肠道运动障碍,内脏过敏,胃适应障碍,肠道屏障功能受损和微生物群失调.
- 肠道微生物群起着至关重要的作用,影响肠道屏障功能,免疫调节,以及FD中的脑肠轴.
- 结合西方医学和TCM的综合治疗策略显示出个性化FD管理的前景.
结论:
- 肠道微生物群是FD的核心参与者,在微生物群-屏障-免疫-大脑-肠轴上的相互作用中介.
- 一种整体的方法,将微生物组的见解与西方-TCM综合疗法整合在一起,为个性化的FD管理提供了一个有前途的框架.
- 对微生物组与宿主相互作用和综合治疗方式的进一步研究是有必要的,以改善FD患者的治疗结果.
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