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细分冷电子断层扫描数据:从细胞景观中提取模型

Danielle A Grotjahn1

  • 1Department of Integrative Structural and Computation Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Current opinion in structural biology
|July 11, 2025
PubMed
概括

深度学习增强了冷电子断层扫描细分,改善了细胞架构分析. 这加速了对宏分子结构及其在细胞内的功能影响的发现.

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
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