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基于流体结构相互作用的未破裂和破裂的中脑动脉动脉瘤的血液动力学

Xiaowen Lu¹, Junchen Chen², Yonghong Liao³

¹Department of Neurosurgery, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.; Department of Neurosurgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

|July 11, 2025

概括

液体结构相互作用分析显示,破裂的内动脉瘤表现出更高的位移,变形和应力. 这些血液动力学因素对于预测动脉瘤破裂风险至关重要.

科学领域:

生物医学工程生物医学工程
流体动力学流体动力学
医疗成像医学成像

背景情况:

传统的内动脉瘤 (IA) 研究往往忽略了动脉壁弹性.
流体结构相互作用 (FSI) 增强了IA血液动力学的模拟现实性.
调查IA血液动力学有助于预测破裂风险.

研究的目的:

为了区分破裂和未破裂的内动脉瘤之间的血液动力学特征.
分析动脉壁弹性在IA破裂中的作用.
建立IA破裂风险评估的血液动力学框架.

主要方法:

对26个内动脉瘤 (13个破裂,13个未破裂) 在中脑动脉分叉处进行了FSI分析.
定量化血液动力学因素:墙壁剪切应力 (WSS),振荡剪切指数 (OSI),位移变形 (DIS),·米塞斯应力 (VMS) 和相对停留时间 (RRT).
在破裂和未破裂的IA组之间比较了这些因素.

主要成果:

与未破裂的病例相比,破裂的IA显示出明显更高的最大时间平均OSI,RRT,DIS和VMS.
缩期分析显示,在破裂的IA中,平均和最大DIS更高,具有更缩和更大的变形区域.
虽然平均时间平均WSS没有差异,但WSS大小在动脉瘤体 (下部) 和母动脉之间有显著差异;大DIS区域与低WSS相对应.

结论:

动脉瘤中增加的DIS,RRT,VMS和OSI是破裂的潜在危险因素.
这些发现强调了在IA临床诊断和治疗计划中考虑这些血液动力学参数的重要性.
FSI分析为IA破裂机制和风险分层提供了宝贵的见解.

关键词:

移位移位移位移位移位流体结构相互作用的相互作用中脑动脉动脉瘤相对居住时间振荡式剪切指数的指数

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