由于双重任务平衡期间认知任务难度增加而引起的皮质变化与老年人和患有帕金森病的患者的姿势不稳定相关
Lin Meng1,2, Hongbo Zhao1, Mengmeng Dong3
1Medical School, Faculty of Medicine, Tianjin University, Tianjin, People's Republic of China.
Journal of neural engineering
|July 11, 2025
概括
认知灵活性随着年龄和帕金森病 (PD) 的增长而下降,影响双重任务的表现. 双重任务期间皮层EEG变化显示注意力缺陷和认知灵活性下降,与PD和老年人的姿势不稳定有关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 老年学是一门学科.
背景情况:
- 在衰老和帕金森病 (PD) 中,认知资源分配的灵活性受到损害.
- 双重任务的表现评估了认知资源的分配,而双重任务期间的皮质激活显示了神经资源的重新分配.
- 在具有不同认知困难的双重任务期间皮层变化及其在PD和老年人 (OA) 中的行为结果仍然未得到充分探索.
研究的目的:
- 为了研究皮质激活的变化,在一个双重任务与增加的认知困难在早期的PD患者,OA和年轻人.
- 检查双重任务期间行为结果,姿势稳定性和脑电图 (EEG) 变化之间的关系.
- 在PD和OA中确定双重任务功能障碍的神经生理生物标志物.
主要方法:
- 采用了一种新的双重任务模式,将平衡维护和视觉工作记忆 (VWM) 结合起来.
- 19名早期PD患者,13名OA和15名年轻成年人在两个难度级别 (2对4平方) 执行VWM任务,同时记录了行为表现,姿势稳定性和32通道EEG.
- 使用单向ANOVA和Spearman的相关性分析来分析组/任务效应和EEG行为关联.
主要成果:
- 无论是PD还是OA组都显示出反应时间的增加,姿势稳定性的降低,P300延长的延迟,以及与较高VWM难度的阿尔法事件相关脱同步 (ERD) 的减少.
- 与OAs相比,PD患者在中部和部区域显著减少了αERD.与OAs相比,PD患者在中部和部区域显著减少了αERD.
- 阿尔法ERD变化与姿势稳定性和临床评分相关,表明皮质活动和运动/认知功能之间存在联系.
结论:
- 在双重任务期间皮质脑电图反应反映了注意力资源重新分配的受损以及PD和OA认知灵活性的减少.
- 观察到的皮层变化与增加的认知负载有关,与姿势不稳定有关.
- 这些发现表明,在衰老和PD中,双重任务功能障碍的潜在神经生理生物标志物.
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