动脉样硬化与癌症之间的深层联系:加勒-3的作用:一篇综述
Xiaoyu Wang1, Benkai Xin1, Jingtong Yang1
1China-Japan Union Hospital of Jilin University, Jilin University, Changchun 130033, Jilin, China.
International journal of biological macromolecules
|July 11, 2025
概括
加勒-3 (Gal-3) 通过影响炎症和细胞生长,作为连接动脉样硬化和癌症的分子桥梁. 向Gal-3为这些主要慢性疾病提供了新的诊断和治疗策略的潜力.
科学领域:
- 生物医学科学 生物医学科学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 动脉样硬化 (AS) 和癌症是导致死亡的主要原因,具有共同的风险因素和机制,如炎症和氧化应激.
- 加勒-3 (Gal-3) 是一种关键蛋白质,调节关键的细胞过程,涉及AS和癌症的发展.
- -3作为分子调解剂,连接了这两种不同的疾病的病理途径.
研究的目的:
- 审查AS和癌症之间的双向关系.
- 阐明Gal-3在AS和癌症之间的分子交叉声调解中的作用.
- 探索Gal-3向治疗的转化潜力.
主要方法:
- 文献综述侧重于分子机制和途径.
- 分析Gal-3在AS和癌症中的炎症,增殖,亡和血管生成中的作用.
- 摘要Gal-3向策略及其临床前/临床结果.
主要成果:
- 在AS和癌症中,Gal-3显著影响炎症微环境,细胞增殖和巨细胞两极分化.
- -3调节关键信号通路 (例如NF-κB,Wnt/β-catenin),作为AS和癌症之间的关键联系.
- 不同的Gal-3向剂,包括抑制剂,多糖,和抗体,显示出治疗前景.
结论:
- -3在动脉样硬化和癌症的发病过程中是一个关键的分子参与者.
- 了解Gal-3介导的交叉声提供了对共享疾病机制的洞察力.
- 准Gal-3为开发AS和癌症的新诊断和治疗方法提供了一个有希望的途径.
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