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患有可疑肺病变的患者的肺移植:单中心回顾性数据分析

Merjem Begic¹, Caroline Hillebrand¹, Florian Frommlet²

¹Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

|July 11, 2025

概括

患有可疑肺病变的患者可以接受肺移植 (LTx). 这些病变中只有很小一部分是癌症,即使在早期的肺癌中,生存率也不会受到影响.

科学领域:

肺部医学肺部医学
移植手术移植手术
在瘤学瘤学.

背景情况:

有可疑肺病变的肺移植候选人通常被排除在外.
关于LTx候选体中这些病变的流行率和恶性病变率的数据有限.

研究的目的:

确定LTx候选人中可疑肺病变的流行率和特征.
评估这些病变的恶性病变率及其对LTx后结果的影响.

主要方法:

从2012年1月到2022年10月,对1070名LTx患者进行了回顾性分析.
损伤特征,组织学发现和术后结果的比较.
计算1年,3年和5年的整体存活率.

主要成果:

7.4% (79/1070) 的LTx接受者有可疑的肺病变.
这些患者中有15.1% (12/79) 确诊肺癌,主要是早期腺癌.
患有恶性/非恶性结节的患者和对照患者在1,3或5年总生存期没有显著差异.

结论:

仅基于未经核实可疑的肺病变排除LTx候选物是不合理的.
在LTx候选人中,小比例的可疑肺病变是恶性的.
在扩张的肺部中,早期的肺癌不会对LTx后的长期生存产生负面影响.

关键词:

肺癌是一种肺癌.肺部移植肺部移植恶性瘤是一种恶性瘤.结节结节结节结节实体器官移植移植实体器官移植

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