休息状态前额叶网络与抑郁症患者失眠的认知功能之间的关联
Xinyu Lin1, Shanling Ji1, Zhuoyan Shan1
1Institute of Mental Health, Jining Medical University, Jining 272002 Shandong Province, China.
Neuroscience
|July 11, 2025
概括
患有失眠的抑郁患者表现出脑前额叶网络受损,影响注意力和记忆等认知功能. 特定前额前部区域的功能连接与认知表现有关,有助于康复策略.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 医疗成像医学成像
背景情况:
- 失眠和抑郁症经常同时发生,往往导致认知缺陷.
- 前额叶皮质在执行功能和情绪调节中起着至关重要的作用.
- 了解这种患者群体认知障碍的神经基础对于有效治疗至关重要.
研究的目的:
- 为了研究休息状态前额叶网络活动与失眠的抑郁患者的认知功能之间的关联.
- 在这个人群中探索前额头功能连接度量的诊断潜力.
主要方法:
- 功能近红外光谱学 (fNIRS) 用于评估静止状态前额叶皮层激活和功能连接 (FC).
- 认知功能使用Trail Making Test (TMT) 和空间跨度测试 (SST) 进行了评估.
- 抑郁症,焦虑和睡眠质量使用患者健康问卷-9 (PHQ-9),通用焦虑障碍尺度-7 (GAD-7) 和匹兹堡睡眠质量指数 (PSQI) 进行评估.
主要成果:
- 与对照组相比,患有失眠的抑郁患者在TMT和SST上表现明显较差.
- 在前额叶区域观察到活性和功能连接的减少,包括前极和轨道前额叶皮层 (FPC-OFC) 和时极和下额叶皮层 (TPC-IPFC).
- 在FPC-OFC地区的FC与认知表现 (TMT和SST) 有显著的相关性.
结论:
- 患有失眠的抑郁患者表现出前额叶网络功能的改变,导致认知缺陷.
- 前额功能连接,特别是在FPC-OFC中,与认知表现密切相关.
- 基于fNIRS的指标显示,在这个患者群体中确定认知障碍和指导康复是有前途的.
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