什么是人类生物监测?
1Institute of Environmental and Occupational Toxicology, Airolo, CH-6780, Switzerland; Università della Svizzera Italiana (USI), Research and Transfer Service, CH-6900, Lugano, Switzerland; Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Nussbaumstrasse 26, D-80336, München, Germany.
Chemico-biological interactions
|July 11, 2025
概括
化学品带来风险,需要更好的暴露科学和风险评估. 生物监测和预测毒理学的进步有助于评估化学物质暴露对健康的影响.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 生物监测 生物监测
背景情况:
- 目前使用的合成化学品超过45万种,引发了对人类和环境健康的担忧.
- 目前的化学品评估是有限的,在环境研究中分析的不到1000个,在生物监测中分析的不到450个.
- 由于化学品的广泛存在和潜在的健康影响,在风险评估中优先考虑化学品至关重要.
研究的目的:
- 审查化学物质优先级,预测毒理学和生物监测方面的最新进展.
- 探索评估化学物质暴露对健康的影响的创新方法.
- 应对暴露科学和风险评估方面的挑战.
主要方法:
- 关于化学物质优先级和预测毒理学的最新文献的综述.
- 检查基因组数据库和生物监测技术的进展.
- 分析解释生物监测数据中的挑战,分析暴露与健康的关联.
主要成果:
- 化学品优先级和预测毒理学的进展为全面的健康影响分析提供了新的机会.
- 生物监测,特别是使用尿路生物标志物,可以检测低水平的暴露,但面临解释的复杂性.
- 不持久化学品的高个体内变异性使单个样本对慢性暴露的评估变得复杂.
结论:
- 完善生物监测方法对于提高暴露与健康关联的可靠性至关重要.
- 由于多因素的影响,将生物监测数据与特定的健康结果联系起来是复杂的.
- 需要进一步的研究来克服在描述现实世界化学物质暴露及其健康影响方面的局限性.
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