相关实验视频

Updated: Sep 16, 2025

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

Published on: November 15, 2019

通过模仿母乳蛋白质的婴儿配方促进肠道屏障功能,在小猪中促进了肠道屏障功能

Yiran Zhang¹, Wen Zhang¹, Yifan Zhang¹

¹Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.

Journal of dairy science

|July 11, 2025

概括

升级婴儿配方,模仿母乳蛋白质,增强肠道发育和小猪的有益细菌. 这项研究支持通过先进的配方设计改善婴儿营养和肠道健康.

科学领域:

* 营养科学营养科学
* 胃肠病学胃肠病学
* 微生物学微生物学

背景情况:

*母乳是婴儿最佳营养来源,其中蛋白质成分是关键.
* 升级婴儿配方旨在复制母乳蛋白质配置,包括乳酸和骨质.
*这些增强蛋白质对婴儿肠道健康的影响需要进一步阐明.

研究的目的:

* 评估蛋白质升级婴儿配方对小猪模型肠道屏障功能的影响.
* 调查升级配方对肠道微生物群组成的影响.
*为优化婴儿配方开发建立科学基础.

主要方法:

* 七天大的小猪在28天内被以标准或蛋白质升级婴儿配方奶粉.
* 评估了肠道形态 (维卢斯高度) 和紧结蛋白 (ZO-1,克劳丁-1,奥克卢丁) 的表达.
*分析了肠道菌群,以确定微生物组成的变化.

主要成果:

* 升级后的配方显著增加了大肠和十二指肠中的小毛高度,约15%.
*在升级配方组中,紧结蛋白ZO-1,Claudin-1和Occludin的表达量增加了1.5至3倍.
*有益的细菌,如Bifidobacterium,在升级后的配方中增加了1.5到2倍.

结论:

* 蛋白质升级婴儿配方奶粉有效促进肠道发育和屏障功能.
*配方积极调节肠道微生物群,有利于有益的细菌.
* 这项研究提供了证据,证明了婴儿配方奶粉设计的改进,以改善肠道健康和营养结果.

关键词:

母乳是母乳中的一种.肠道屏障障碍物肠道屏障障碍物婴儿配方奶粉的使用方法猪仔猪小猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪

更多相关视频

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

相关概念视频

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...