巴塞尔长期COVID队列研究 (BALCoS):前性队列研究的协议
Stefan Rohner1,2, Rebekka Schnepper2,3, Gunther Meinlschmidt1,2,4,5
1Faculty of Medicine, University of Basel, Basel, Switzerland.
BMJ open
|July 11, 2025
概括
巴塞尔长期COVID队列研究 (BALCoS) 通过评估临床,功能和心理社会因素来调查COVID-19后的状况 (PCC). 这项研究旨在增强对长期COVID复杂性及其对日常生活的影响的理解.
科学领域:
- 医学 医学 医学 医学 医学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- SARS-CoV-2 流行病导致了 COVID-19 后疾病 (PCC) 影响许多个人的重大全球健康挑战.
- PCC的特点是持续的症状,如疲劳和认知困难,影响日常生活.
- PCC越来越被认为是一种由生物医学,心理和社会决定因素影响的多因素状况.
研究的目的:
- 为了提高对COVID-19后状况 (PCC) 的理解.
- 通过重复评估,捕捉PCC的综合临床,功能和心理社会方面.
- 在一年内纵向跟踪PCC的进展和影响.
主要方法:
- 未来的,单个地点的队列研究 (巴塞尔长期COVID队列研究 - BALCoS).
- 包括患有SARS-CoV-2感染后持续症状的成年人 (≥18岁).
- 使用标准化心理测量评估,体能测试,生态瞬间评估 (EMA),神经认知测试和在多个时间点收集血液样本.
- 包括面对面和远程评估选项.
主要成果:
- 本节不适用,因为摘要描述的是研究方案,而不是结果.
- 这项研究是探索性的,目标样本大小为120名参与者.
- 数据收集包括基线,3个月,6个月和12个月的随访.
结论:
- 该BALCoS协议为深入,多学科研究COVID-19后的条件提供了一个框架.
- 预计这些发现将有助于更好地了解PCC复杂的病因和影响.
- 该研究已注册 (NCT05781893),并获得相关道德委员会的批准,并计划通过同行评审的出版物传播.
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