在二双胞胎怀孕中,孕妇在第二个三个月的脂质水平与早产之间的关联:在中国进行的一项回顾性研究
Pingping Su1, Wenni Zhou2, Huan Han1
1Department of Obstetrics, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
BMJ open
|July 11, 2025
概括
怀孕第二个三个月的高孕产妇甘油三会增加双双胞胎的早产风险,特别是那些通过IVF-ET怀孕的双胞胎. 这一发现凸显了双胞胎怀孕期间监测脂质水平的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 生殖内分泌学 生殖内分泌学
背景情况:
- 双胞胎怀孕中早产仍然是一个重大问题.
- 孕产妇的脂质样本可能会影响怀孕的结果.
- 了解这些关联可以为临床管理提供信息.
研究的目的:
- 调查第二个三个月的母体脂质水平与二双胞胎怀孕中早产风险之间的关联.
- 为了确定母体甘油三 (mTG) 和总胆固醇 (TC) 水平是否可预测早产.
- 在体外受精-胚胎移植 (IVF-ET) 的背景下探索这些关联.
主要方法:
- 回顾性单中心研究,包括745例二双胞胎怀孕.
- 孕妇的血清甘油三和总胆固醇测量在第二个三个月.
- 后勤回归分析用于评估与早产的关联.
主要成果:
- 怀孕第二季度高水平的孕产妇甘油三与早产风险增加显著相关 (aOR=1.55).
- 高的mTG水平也与早产早产的风险更高有关 (aOR=2.01).
- 这种关联在IVF-ET怀孕的妇女中更为明显,特别是早产早产 (aOR=3.07).
结论:
- 在怀孕的第二个三个月内,母亲的高甘油三水平是双双胞胎早产的危险因素.
- 过早分娩的风险,特别是早期过早分娩的风险,在IVF-ET怀孕的双胞胎怀孕中增加了高母体甘油三.
- 监测母亲的脂质样本可能有利于双胞胎怀孕的风险分层.
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