管理TBSRTC III甲状腺结节:评估重复FNA,分子测试和手术
Christopher Dilli1, William Mi2, Daniel L Miller3
1Saint Louis University School of Medicine, St. Louis, Missouri.
Journal of the American Society of Cytopathology
|July 11, 2025
概括
重复细针吸收 (FNA) 是一种具有成本效益的策略,用于管理具有不确定的重要性 (AUS) 的异型性甲状腺结节,在不影响恶性瘤或手术率的情况下解决了近50%的病例.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 诊断细胞病理学诊断细胞病理学
背景情况:
- 甲状腺结节很常见,大多数是良性的.
- 不确定的意义上的非典型性 (AUS) 或贝塞斯达III结节带来了管理挑战.
- 目前的选择包括监视,重复FNA,分子测试和手术,而分子测试成本昂贵.
研究的目的:
- 评估AUS结节重复FNA的可行性和成本效益.
- 为了将重复FNA结果与分子测试和手术干预进行比较.
- 评估预视镜超声波在风险分层中的有用性.
主要方法:
- 来自5家医院的131个AUS结节 (2018-2024) 的回顾性多机构研究.
- 由初始管理分层的结节:重复FNA,分子测试或手术.
- 临床分析,超声波发现,恶性瘤率和估计成本 (医疗保险费率) 的分析.
主要成果:
- 重复FNA在48.7%的病例中产生良性诊断,在35.9%的病例中产生AUS.
- 重复FNA是最具成本效益的管理策略.
- 在重复FNA和分子测试之间,恶性瘤或手术干预率没有显著差异.
- 声源性焦点是唯一一个与恶性瘤有显著关联的超声波发现.
结论:
- 重复FNA是AUS结节的成本有效的初始方法,大约50%的病例得到解决.
- 关于恶性瘤和手术干预的结果与分子测试相似.
- 预先检查超声波在预测AUS结节的恶性瘤风险方面具有有限的价值.
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