关键饮食成分的量化摄入量和患类风湿性关节炎的风险:来自嵌套病例控制研究的结果
Rebecka Bäcklund1, Ulf Bergström1, Michele Compagno1
1Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Annals of the rheumatic diseases
|July 11, 2025
概括
遵守瑞典饮食指南,特别是减少红肉和增加蔬菜/水果,可能会降低类风湿性关节炎 (RA) 风险. 较高的红肉摄入量与增加的血清阳性RA风险有关.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 是一种具有复杂病因的慢性自身免疫性疾病.
- 饮食模式越来越被认为是包括RA在内的慢性疾病的潜在可修改的风险因素.
研究的目的:
- 检查遵守2015年瑞典基于食品的饮食指南 (SDG) 与患类风湿性关节炎 (RA) 的风险之间的关联.
- 调查可持续发展目标的特定组成部分,如蔬菜,水果和肉类摄入量,与RA风险相关.
主要方法:
- 一个嵌套的病例控制研究,利用来自前的马尔默饮食和癌症研究 (MDCS) 的数据.
- 饮食摄入量在基线时使用经过验证的饮食史方法进行评估.
- 通过注册链接和医疗记录审查确定了事件RA病例,对照对年龄,性别和纳入年份进行了匹配. 使用SDG评分 (SDGS) 量化了对SDG的坚持.
- 统计分析包括多变量逻辑回归和受限立方线 (RCS).
主要成果:
- 总共有305个事件RA病例被确定.
- 建议摄入蔬菜/水果 (>400克/天) 和较低摄入红肉/加工肉 (<500克/周) 与降低RA风险相关 (OR分别为0.64和0.60).
- 红色/加工肉类摄入量与RA风险之间呈正线性关联,而蔬菜/水果则呈负相关性. 红色/加工肉和RA风险之间的关联在血清阳性RA病例中更为明显.
结论:
- 更高的红肉和加工肉的消费与患有血清阳性类风湿性关节炎的风险增加有关.
- 增加蔬菜和水果的摄入量可能有助于降低类风湿性关节炎的整体风险.
相关概念视频
Genome-wide Association Studies-GWAS
14.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.3K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
426
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
426
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
178
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
178
The JAK-STAT Signaling Pathway
9.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.3K
Rheumatic Heart Disease I: Introduction
48
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
48
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K


