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对 synaesthesia 与神经发育和精神病特征之间的联系的遗传和环境贡献:一项双胞胎研究
Janina Neufeld1,2, Tessa M van Leeuwen3,4, Ralf Kuja-Halkola5
1Center of Neurodevelopmental Disorders at Karolinska Institutet (KIND), Department of Women's and Children's Health, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Janina.Neufeld@ki.se.
Translational psychiatry
|July 11, 2025
概括
麻醉是一种感官体验,与各种神经发育和精神疾病有关,而不仅仅是自闭症. 遗传因素对这些关联有很大影响,特别是强迫症特征.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 麻醉包括经历由特定输入触发的额外感觉.
- 它在患有自闭症谱系障碍和其他神经发育疾病的个体中更为普遍.
- 之前的研究表明, synaesthesia 和各种精神疾病之间存在联系.
研究的目的:
- 调查自我报告的麻醉和青少年八种精神/神经发育特征之间的关联.
- 通过双胞胎模型估计对这些关联的遗传和环境贡献.
主要方法:
- 利用经典的双胞胎建模来分析18岁双胞胎的数据.
- 评估了自我报告的麻醉症和八个精神病/神经发育特征 (自闭症,多动症,强迫症,焦虑症,抑郁症,类似精神病的经历,饮食障碍, (低) 躁狂).
主要成果:
- 所有评估的神经发育/精神病学特征与共觉症有正相关.
- 观察到最强的关联是强迫症特征 (r=0.28).
- 遗传因素解释了大多数关联的50%以上;非共享的环境因素有不同的影响,而共享的环境影响是可以忽略的.
结论:
- 麻醉症与以前认为的更广泛的神经发育/精神病特征有关,特别是强迫症特征.
- 遗传因素主要影响这些关联,这表明 synaesthesia 和几个神经发育/精神疾病之间有共同的遗传基础.
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