在瑞士的儿童中使用具有药物遗传学建议的药物
Nina L Wittwer1,2, Christoph R Meier1,2,3, Carola A Huber4
1Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
The pharmacogenomics journal
|July 11, 2025
概括
在瑞士儿童中,药物遗传学 (PGx) 药物使用很常见,超过66%的儿童声称至少服用了一种PGx药物. 这突显了药物遗传测试的潜力,有利于儿科护理.
科学领域:
- 儿科药理学 儿科药理学
- 遗传学和基因组学 在
- 临床药房 临床药房
背景情况:
- 药物遗传学 (PGx) 的实施在成年人中越来越多,但其在儿科群体中的应用理解较少.
- 了解儿童的PGx药物使用对于优化治疗和尽量减少药物不良反应至关重要.
研究的目的:
- 调查瑞士儿科人口中药物遗传学 (PGx) 药物的使用模式.
- 确定最常用的PGx药物和关键基因,涉及到儿童潜在的药物基因相互作用.
主要方法:
- 对Helsana医疗保险索赔数据的分析,从2017年到2021年对持续保险的儿童进行分析.
- 鉴定了82种PGx药物与儿科指南注释,这些注释与来自药物基因组学知识库的24个基因的变异有关.
- 药物使用率的计算和流行药物基因相互作用的识别.
主要成果:
- 在159,172名持续保险儿童中,66.1%的儿童至少申请了一种PGx药物.
- 最常见的PGx药物是易布洛芬 (59.1%),丹塞 (8.3%) 和甲 (7.5%).
- 七个基因 (CYP2C9,CYP2D6,DPYD,CYP2C19,MT-RNR1,CACNA1S,RYR1) 占潜在药物基因相互作用的96%以上.
结论:
- 瑞士儿童中有很大一部分接触PGx药物,这表明PGx测试有很大的潜力来个性化儿科药物治疗.
- 这些发现支持将PGx测试纳入常规儿科护理,以提高药物的有效性和安全性.
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