肠道微生物群和大脑中居住的CD4+ T细胞塑造了自闭症谱系障碍的行为结果
John Chulhoon Park1, Min-A Sim1, Changhon Lee1,2
1Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
Nature communications
|July 11, 2025
概括
这项研究揭示了自闭症谱系障碍 (ASD) 中的肠-免疫-大脑轴. 没有细菌的小鼠表现出更好的行为,这表明肠道微生物影响神经炎症和ASD症状.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,其肠-大脑轴机制尚不清楚.
- 新出现的证据将肠道微生物群与ASD病原发生联系起来.
- 了解肠-免疫-大脑连接对于自闭症研究至关重要.
研究的目的:
- 用无菌小鼠模型研究肠道微生物群在ASD中的作用.
- 确定影响ASD肠道-免疫-大脑轴的微生物和代谢因素.
- 评估对ASD进行潜在的益生菌干预.
主要方法:
- 为ASD开发一个无细菌的BTBR小鼠模型.
- 评估与自闭症相关的行为和大脑中T细胞种群.
- 微生物和代谢分析,包括in silico代谢物预测.
- 给 *Limosilactobacillus reuteri* IMB015 (IMB015) 和行为评估.
主要成果:
- 肠道微生物群的缺失改善了ASD行为,并减少了雄性小鼠的炎症性脑T细胞.
- CD4+ T细胞枯竭减轻了神经炎症和ASD行为.
- 确定了特定的微生物和新陈代谢调节剂,包括谷氨酸/GABA比率和3-糖酸.
- IMB015的使用使谷氨酸/GABA比率正常化,减少神经炎症,改善行为.
结论:
- 在ASD中存在肠道-免疫-大脑轴,其中肠道微生物群调节大脑居民免疫细胞和行为.
- 肠道微生物群及其代谢物是神经炎症和ASD相关行为的关键调节者.
- *Limosilactobacillus reuteri* IMB015显示出作为治疗ASD的益生菌的希望.
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