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Updated: Sep 16, 2025

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
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TRF1依靠叉子逆转来防止人类端粒脆弱

Mélina Vaurs1, Eloïse Claude1, Elia Zanella2

  • 1Genetic & Epigenetic Alterations of Genomes Unit, de Duve Institute, UCLouvain, Brussels, Belgium.

Nature communications
|July 11, 2025
PubMed
概括

端粒复制脆弱性由TRF1减少,这促进了叉反转和重新启动. 这个过程涉及端粒酶,TFIIH和PrimPol,并且依赖于RNA:DNA杂交物来成功地复制人类端粒.

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