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Updated: Sep 16, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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TRIM33的损失减少了雄激素受体的转录输出和H2BK120的无处不在

Nils Eickhoff1,2, Janina Janetzko1,2,3, Nuno Padrão1,2

  • 1Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Communications biology
|July 11, 2025
PubMed
概括

含有33 (TRIM35) 的三方基因与前列腺癌细胞中的雄激素受体 (AR) 相互作用. TRIM35通过影响H2BK120无化来增强AR活性,而不是影响AR蛋白的稳定性.

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