Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

11.3K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.3K
Proteomics01:33

Proteomics

7.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Metabolomic insights into flavonoid migration and bioactivity enhancement in Apocynum venetum tea during hot-water brewing.

Food chemistry·2026
Same author

Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription.

Science (New York, N.Y.)·2026
Same author

AURORA A interacts with DICER and SETD2 to promote S-phase progression.

EMBO reports·2026
Same author

Long-term light grazing facilitates topsoil carbon accumulation in desert steppes by disrupting preferential flow networks.

Journal of environmental management·2026
Same author

Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance.

Science advances·2026
Same author

Feasibility of left subcostal single-incision laparoscopic surgery for pediatric left retroperitoneal space-occupying lesions.

Pediatric surgery international·2026
Same journal

Computing inspired by the brain: a journey from algorithms to organoids.

Nature computational science·2026
Same journal

Systematic bottom-up coarse-graining of hydrated excess proton transport across scales.

Nature computational science·2026
Same journal

Gaining biological insights through supervised data visualization.

Nature computational science·2026
Same journal

The inequalities of GPU access.

Nature computational science·2026
Same journal

Social technologies need societal alignment.

Nature computational science·2026
Same journal

The Quantum Optimization Benchmarking Library.

Nature computational science·2026
查看所有相关文章

相关实验视频

Updated: Sep 8, 2025

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

823

使用FedProt进行保护隐私的多中心差异蛋白质丰度分析.

Yuliya Burankova1,2, Miriam Abele3,4, Mohammad Bakhtiari5

  • 1Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. yuliya.burankova@tum.de.

Nature computational science
|July 11, 2025
PubMed
概括
此摘要是机器生成的。

通过FedProt,可以在各个机构进行保护隐私的蛋白质组分析. 这种联合学习工具确保了准确的差异蛋白质量化,而不会影响患者数据的隐私.

更多相关视频

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

12.9K
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.1K

相关实验视频

Last Updated: Sep 8, 2025

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

823
Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

12.9K
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.1K

科学领域:

  • 蛋白质组学是指蛋白质组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 定量质谱法允许大规模的蛋白质量化.
  • 对分布式患者数据的协作分析增强了统计能力,但存在隐私风险.

研究的目的:

  • 介绍FedProt,这是一个新的隐私保护工具,用于协作差异蛋白质丰度分析.
  • 使用联合学习实现安全,多机构的蛋白质组数据分析.

主要方法:

  • 开发了FedProt,利用联合学习和添加式秘密共享.
  • 创建了两个新的多中心数据集 (大肠杆菌和人血清) 用于评估.
  • 我们将FedProt的准确性与现有方法 (如DEqMS) 进行了比较.

主要成果:

  • FedProt的准确度与集中分析 (DEqMS) 相同,差异微不足道 (≤4×10−12).
  • 与集中分析相比,元分析方法在结果中显示出显著的差异.
  • 在微生物和人血清数据集上证明了FedProt的有效性.

结论:

  • FedProt为协作蛋白质组分析提供了一个安全而准确的解决方案.
  • 该工具有效地解决了多机构数据共享中的隐私问题.
  • 在保护隐私的计算生物学中,FedProt代表了重大进步.