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化学疗法期间血液恶性瘤患者的运动干预措施的安全性,可行性和有效性:系统性审查和元分析
Yuqin Luo1,2, Yufang Ren2,3, Yuan Li4,5
1Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
概括
运动干预措施对于接受化疗的血液恶性瘤 (HM) 患者来说是安全和可行的,显著改善身体健康并减少抑郁症. 对焦虑,疲劳和生活质量的影响需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 血液学 血液学 血液学
背景情况:
- 血液性恶性瘤 (HM) 的化疗可能会对患者的身体和心理健康产生负面影响.
- 正在探索运动干预措施以减轻这些不良影响.
- 关于HM化疗期间运动的有效性和安全性的证据正在演变.
研究的目的:
- 系统地审查和评估化学疗法期间HM患者的运动干预措施的安全性,可行性和有效性.
- 评估运动对身体健康,心理健康和生活质量的影响.
主要方法:
- 在2024年2月之前,对9个电子数据库进行了系统搜索.
- 该审查遵循了Cochrane指南和PRISMA检查清单,包括灵敏度,子组和元回归分析.
- 包括33项研究,其中19项正在进行元分析;其他研究则以叙事方式总结.
主要成果:
- 运动干预被发现是安全的和可行的,大多数研究报告的参与率很高.
- 在体能参数中观察到显著的改善,包括计时步行距离,计时上升和移动测试,以及峰值氧气消耗.
- 运动干预导致抑郁症得分显著降低,但对焦虑和生活质量的影响并不显著. 疲劳的证据是不确定的.
结论:
- 运动干预似乎对接受化疗的HM成年患者来说是安全和可行的.
- 运动可以改善身体健康,并减少这种患者群体的抑郁症.
- 需要进一步进行更长时间的随访大规模试验,以澄清对生活质量,疲劳和焦虑的影响.
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