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Updated: Sep 16, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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基因组5mC甲基化抑制了基因组中G-四重复结构的形成

Kangkang Niu1, Lijun Xiang2, Xiaojuan Zhang2

  • 1Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China. kkniu@m.scnu.edu.cn.

Genome biology
|July 11, 2025
PubMed
概括

基因甲基化 (5mC) 抑制了G-四重复 (G4) 的形成,影响了基因转录. 减少甲基化增加G4s和基因表达,揭示了一个关键的表观遗传调节机制.

关键词:
通过DNA甲基化.表观遗传调节 表观遗传调节在G-quadruplex的形成.基因表达 基因表达 基因表达

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