相关实验视频

Updated: Sep 16, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

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针对性进化和高亲和度ICOS-L变体的模块化集成,用于强大的T细胞介导瘤消除

Ji Yeon Ha1,2, Tae Wook Song3, Petrina Jebamani4

  • 1Department of Biomedical Sciences, Graduate School, Korea University, Seoul, 02841, Republic of Korea.

Journal of biological engineering
|July 11, 2025
PubMed
概括

改造的ICOS配体 (Y8) 对增强的T细胞激活具有100倍的亲和力. 这种变体在与抗体融合时增强了抗PD-1癌症免疫疗法,改善了瘤细胞溶解.

关键词:
定向进化是指导进化的.在ICOS-L中,免疫检查点融合检查点模块化生物学的模块化生物.合成免疫调节器 合成免疫调节器同时刺激T细胞共刺激.

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