相关实验视频

Updated: Sep 16, 2025

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

乳腺癌患者体质指数与新辅助化疗反应之间的关联

Jonas Busk Holm^1,2, Stine Blaabjerg Skovbjerg^3,4, Hanne Melgaard Nielsen⁴

¹Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. jonasbuskholm@oncology.au.dk.

Breast cancer research : BCR

|July 11, 2025

概括

肥胖与乳腺癌患者接受新辅助化疗的病理完整反应 (pCR) 率较低有关. 与正常体重患者相比,超重和肥胖个体的pCR实现的几率较低.

科学领域:

在瘤学瘤学.
临床研究临床研究
流行病学流行病学

背景情况:

肥胖 (身体质量指数≥30 kg/m2) 与较差的乳腺癌预后有关.
肥胖对新辅助化疗反应的影响尚不清楚.
这项研究调查了乳腺癌患者的肥胖和病理完整反应 (pCR) 之间的关联.

研究的目的:

为了确定肥胖是否会影响新辅助化疗后实现pCR的可能性.
分析身体质量指数 (BMI) 类别与pCR率之间的关系.
根据乳腺癌亚型和更年期状态来探索这种关联的潜在变化.

主要方法:

在丹麦,分析了2016-2020年期间接受新辅助化疗 (EC-TAX,+/- trastuzumab/pertuzumab) 的1819名乳腺癌患者队列.
根据BMI对患者进行分类:正常体重 (18.5-25 kg/m2),超重 (25-30 kg/m2) 和肥胖 (≥30 kg/m2).
多变量逻辑回归模型,根据年龄和更年期状态进行调整,用于计算pCR的几率比率 (ORs),按ER和HER2状态分层.

主要成果:

总的来说,在1819名患者中,417名患者实现了pCR.
与体重正常的患者相比,超重和肥胖的患者pCR的几率明显较低 (分别为ORadj=0.78和ORadj=0.73).
肥胖患者的pCR率较低,在HER2+瘤和绝经后妇女中更为明显.

结论:

超重和肥胖与接受新辅助化疗的乳腺癌患者实现pCR的几率降低有关.
BMI和pCR之间的关联可能因乳腺癌亚型 (ER/HER2状态) 和更年期状态而异.
在乳腺癌患者中,BMI可能作为pCR的预后标志物.

关键词:

体重指数 (Body Mass Index) 是一个指数.新辅助化学疗法新辅助化学疗法肥胖问题肥胖问题体重过重的情况病理完整反应的病理完整反应.

更多相关视频

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

相关概念视频

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Dose-Response Relationship: Overview

Dose-Response Relationship: Overview

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...