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Updated: Sep 16, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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GPCR-A17 MAAP:映射调制剂,激动剂和对抗剂,以预测下一个生物活性标

Ana B Caniceiro1,2,3,4, Ana M B Amorim1,2,3,4, Nícia Rosário-Ferreira1,2,3,4

  • 1CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Ed FMUC, Piso 1, 3004-504, Coimbra, Portugal.

Journal of cheminformatics
|July 11, 2025
PubMed
概括

本研究介绍了GPCR-A17调节器,激进分子,对抗分子预测器 (MAAP),这是一个集体机器学习模型,用于预测G蛋白结合受体相互作用. 通过准确识别GPCR-A17标的潜在治疗剂,MAAP加速了药物发现.

关键词:
激进主义者的激进主义者敌对者的敌人 敌对者结合亲和力 (Ki) 是结合的亲和力.药物发现 药物发现组合学习学习 组合学习在GPCR亚家族A17中,A17是A17亚家族.调制器调制器是一个模拟器.

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