评估基于血液的诊断生物标志物用于犬类认知功能障碍综合征
Jun-Won Yoon1, Chan-Sik Nam1, Kwang-Sup Lee1
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Animals : an open access journal from MDPI
|July 12, 2025
概括
血清神经丝光链 (NfL) 显示出作为血液生物标志物对犬类认知功能障碍综合征 (CDS) 的承诺. 升高的NfL水平与CDS严重程度相关,在与行为评估相结合时,可能会改善诊断.
科学领域:
- 兽医神经学 兽医神经学
- 生物标志物发现发现
- 神经退行性疾病 神经退行性疾病
背景情况:
- 狗的认知功能障碍综合征 (CDS) 是老年狗的一种进展性神经退行性疾病.
- CDS是人类阿尔茨海默病的自然模型.
- 精确的诊断和CDS的分期对于有效的管理至关重要.
研究的目的:
- 评估血液生物标志物 (粉样β 40/42,NfL,GFAP) 用于诊断和分期CDS.
- 评估是否将生物标志物与行为问卷结合起来可以提高诊断可靠性.
主要方法:
- 评估了77只狗 (健康对照和CDS病例).
- 使用CCDR,CADES和CCAS问卷进行行为评估.
- 血Aβ40,Aβ42,GFAP和血清NfL水平通过ELISA测量.
主要成果:
- 在患有CDS的狗中,血清NfL水平显著升高 (p < 0.05).
- 在Aβ40,Aβ42,GFAP和CDS阶段之间没有发现显著的关联.
- ROC分析表明,NfL在诊断CDS方面的潜力,AUC从0.722到0.777.7之间.
结论:
- 血清NfL是犬类认知功能障碍综合征的一个有前途的血液生物标志物.
- NfL水平与CDS严重程度相关,有助于诊断和分期.
- 将NfL测量与行为问卷相结合,可以提高兽医实践中的诊断准确性.
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