来自猫咪牛奶的乳酸细菌对益生菌性质的表征和评估
Haohong Zheng1, Jiali Wang1, Yunjiang Liu1
1Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Animals : an open access journal from MDPI
|July 12, 2025
概括
研究人员探索了猫奶中的乳酸细菌作为抗生素的潜在益生菌替代品. 一个菌株Lactobacillus plantarum M3表现出强大的生存能力,粘附性和抗菌特性,表明它有望治疗猫的多药耐药性感染.
科学领域:
- 兽医微生物学 兽医微生物学
- 益生菌和益生菌和益生菌.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 过度使用抗生素助长多药耐药 (MDR) 细菌,这是一个重大的公共卫生问题.
- 物可以携带并将MDR细菌传播给人类,因此需要替代治疗方法.
- 猫奶是隔离有益的微生物的潜在来源,如乳酸细菌 (LAB).
研究的目的:
- 识别和评估猫奶中的乳酸细菌作为抗生素的潜在益生菌替代品.
- 评估隔离的LAB菌株的体外益生菌特性.
- 确定这些LAB菌株在对抗猫科动物多药耐药细菌方面的潜力.
主要方法:
- 从猫奶中分离和识别乳酸细菌.
- 在实验室中对LAB菌株进行评估,包括生长动力学,粘附性,安全性和抗病原性活性.
- 评估抗氧化能力,代谢物产生,耐压力 (胆盐,酸性状况,胃/肠汁),自聚,疏水性和抗菌活性 (协聚,牛津杯测定).
主要成果:
- 三个LAB菌株被分离出来:两个乳酸菌植物菌 (M2,M3) 和一个Weissella confusa (M1).
- 菌株M2和M3在各种压力条件下表现出强大的生存能力.
- 植物乳杆菌M3表现出显著的自我聚合 (73.39%),疏水性 (62.16%),非溶血性活性,以及对病原体有强大的抗菌作用.
结论:
- 与其他孤立菌株相比,乳酸菌植物菌M3具有优越的益生菌特性.
- 这种菌株显示出作为抗生素辅助或替代品的潜力,用于治疗猫的多药耐药细菌感染.
- 对猫类益生菌的进一步研究可能为对抗伴侣动物抗菌素耐药性提供新的解决方案.
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