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探索红葡萄皮提取物聚的生物可用性:一个Caco-2细胞模型研究

Edurne Elejalde^1,2, Rosa María Alonso², María Carmen Villarán¹

¹TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Álava, 01510 Miñano, Álava, Spain.

Foods (Basel, Switzerland)

|July 12, 2025

概括

葡萄中的多醇.

科学领域:

营养科学营养科学
药理学药理学是指药理学的学科.
细胞生物学细胞生物学

背景情况:

葡萄富含多,这些化合物对健康有好处.
聚醇的生物可用性对于它们的作用至关重要.
有限的数据存在葡萄多的生物可用性.

研究的目的:

为了研究红葡萄皮提取物 (GSE) 的九种多的肠道透性.
通过Caco-2细胞模型评估这些化合物的运输效率 (TE).

主要方法:

利用Caco-2细胞模型模拟人类肠道上皮质.
分析了三种安托西亚宁,三种黄醇,两种基酸和一种基酸的运输.
测试了GSE的两个度 (15 mg/mL和22 mg/mL).

主要成果:

马尔维丁-3-O-葡萄糖化物在酸中具有1.08%的TE.
凯姆菲洛-3-葡萄糖化物在黄醇中显示出最高的TE (130%).
酸在整体上表现出最高的TE (188%).

结论:

酸和kaempferol-3-glucoside显示出显著的肠道运输.
对于像马尔维丁-3-O-葡萄糖化物这样的安东素,只观察到有限的运输.
这些发现提供了关于葡萄多的吸收机制和生物活性的见解.

关键词:

在Caco-2细胞中.葡萄皮是葡萄的皮肤.在体外的生物可用性.肠道的通透性肠道的通透性聚醇是一种多醇.

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