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齐恩/酸 (FA) - pectin (PEC) /Chitosan (CS) 纳米复合物的保护作用在小鼠的DSS诱导的性结肠炎上

Yifei Guo¹, Xinyu Yu¹, Rongrong He¹

¹Hainan University-HSF/LWL Collaborative Innovation Laboratory, College of Food Sciences & Engineering, Hainan University, 58 People Road, Haikou 570228, China.

Foods (Basel, Switzerland)

|July 12, 2025

概括

这项研究开发了一种新的Zain/ferulic acid-pectin/chitosan纳米复合物用于性结肠炎 (UC) 治疗. 针对结肠的系统有效地提供了酸,在UC小鼠中显示出改善的治疗效果.

科学领域:

生物材料科学生物材料科学
胃肠病学胃肠病学
药理学药理学是指药理学的学科.

背景情况:

酸 (FA) 显示了性结肠炎 (UC) 的治疗潜力.
环境敏感性和酶降解限制了FA在UC治疗中的有效性.
需要一个针对结肠的输送系统来增强FA的治疗效果.

研究的目的:

开发一种针对结肠的Zain/FA-pectin (PEC) /chitosan (CS) 纳米复合物,用于UC治疗.
研究UC小鼠中开发的纳米复合物的保护作用和调控机制.

主要方法:

用优化比例制造Zin/FA-PEC/CS纳米复合物的制造.
纳米复合物的特性,包括封装效率和负载能力.
在UC小鼠模型中评估纳米复合物稳定性,FA释放概况和治疗效果.

主要成果:

实现了最佳的封装效率 (60.1%) 和负载能力 (26.2%).
纳米复合体在模拟消化过程中表现出良好的热/储存稳定性和持续的FA释放.
扎因/FA-PEC/CS纳米复合物通过调节炎性细胞因子,氧化应激和肠道微生物群,显著缓解了UC症状.

结论:

Zein/FA-PEC/CS纳米复合体代表了UC治疗中FA的一个有前途的结肠向输送系统.
与未封装的FA相比,开发的系统在缓解UC方面表现出更高的疗效.
这种方法提供了一种通过向药物输送来管理性结肠炎的新策略.

关键词:

在 DSS 中使用 DSS.封装的封装方式铁酸是什么意思铁酸是什么意思我们的肠道微生物群.一个纳米复杂的纳米.性结肠炎是一种

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