慢性铜过载会触发中肠PVAT的炎症,同时会改变与宁-血管素系统相关的通路
Nina Bruna de Souza Mawandji1, Nayara Ariel da Silva Lisboa2, Karoline Neumann Gomes1
1Postgraduate Program in Physiology Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29043-900, ES, Brazil.
Nutrients
|July 12, 2025
概括
高铜摄入量会破坏周血管脂肪组织 (PVAT) 功能,增加炎症并通过AT1R-TLR4-血管新生II通路改变血压调节. 洛萨坦治疗部分扭转了这些有害影响.
科学领域:
- 生理学 生理学 生理学
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 铜是必不可少的,但过量摄入会损害血管反应能力和血压.
- 周血管脂肪组织 (PVAT) 在血管恒温中发挥着至关重要的作用.
- 铜过载对介质PVAT功能的影响仍未得到充分研究.
研究的目的:
- 为了研究慢性铜过载对中腔PVAT分泌功能的影响.
- 阐明氨酸-血管氨系统 (RAS) 和炎症标志物在铜诱导的PVAT功能障碍中的作用.
- 评估洛萨坦在缓解这些变化的潜在治疗效果.
主要方法:
- 威斯塔大鼠接受了长期的铜过载 (建议剂量的2倍) 或对照条件30天.
- 这些组包括对照组,铜组,洛萨坦 (AT1R抗剂) 和铜+洛萨坦组.
- 介肠PVAT经历了形态测量,基因和蛋白质表达分析;血清被生物化学分析.
主要成果:
- 铜过载增加了脂肪细胞大小,减少了脂解,改变了脂蛋白分泌 (增加了TNF-α,PAI-1;减少了IL-10).
- 在PVAT中观察到炎症标记物 (MCP-1,F4/80,CD86,TLR4) 和RAS成分 (ACE1,AT1R) 的升调,血清血管新素II的增加.
- 洛萨坦治疗减弱了铜诱导的脂肪细胞缩,TNF-α分泌和TLR4,F4/80和阿基因酶-1的表达.
结论:
- 长期高铜暴露会破坏中介管PVAT分泌功能,促进炎症和改变局部RAS.
- AT1R-TLR4-血管新生素II信号通路与铜诱导的PVAT功能障碍有关.
- 向AT1R可能提供针对铜诱导的血管和炎症变化的治疗策略.
相关概念视频
01:24Chronic Pancreatitis I: Introduction
166
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
166
01:17Gastritis-II: Pathophysiology
566
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
566
01:29Chronic Pancreatitis II: Collaborative Care
130
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
130
01:17Chronic Bowel Disorders: Introduction
541
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
541