超加工食品和与代谢功能障碍相关的脂肪性肝病 (MASLD):迄今为止的证据是什么?
Eleni V Geladari1, Dimitris Kounatidis2, Gerasimos Socrates Christodoulatos3
1Third Department of Internal Medicine, Evangelismos General Hospital, 10676 Athens, Greece.
Nutrients
|July 12, 2025
概括
超加工食品 (UPF) 的消费与代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 减少UPF摄入量可能有助于预防MASLD进展到更严重的肝病.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 超加工食品 (UPF) 经过广泛的工业加工,包括添加剂和化学品.
- UPF与胰岛素耐药性,2型糖尿病 (T2D) 和肥胖等代谢障碍有关.
- 新出现的证据将UPF消费与代谢功能障碍相关的脂肪性肝病 (MASLD) 联系起来.
研究的目的:
- 审查MASLD.的病理生理机制.
- 检查UPF过度消费在MASLD发展中的作用.
- 探索防止MASLD进展为代谢功能障碍相关的脂肪肝炎 (MASH),纤维化和肝硬化的策略.
主要方法:
- 文献综述和当前研究数据的综合.
- 对MASLD涉及的病理生理路径的分析.
- 评估UPF对肝脏健康的影响.
主要成果:
- 高能量密度和营养质量差的UPF有助于肝脏脂肪的积累.
- 对UPF的过度消费是MASLD发展的一个合理因素.
- 特定的UPF成分可能会加剧肝炎和纤维化.
结论:
- 尽量减少UPF消耗是预防和管理MASLD的关键策略.
- 需要进一步的研究来阐明特定的UPF饮食模式及其对肝病的影响.
- 公共卫生倡议应侧重于减少UPF摄入量,以应对MASLD的流行率上升.
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